Modern Chillicothe was the center of the ancient Hopewell tradition, which flourished from 200 BC until 500 AD.
This Amerindian culture had trade routes extending to the Rocky Mountains.
34.6% of all households were made up of individuals and 14.3% had someone living alone who was 65 years of age or older.
The average household size was 2.25 and the average family size was 2.87. 21.8% of residents were under the age of 18; 7.7% were between the ages of 18 and 24; 24.8% were from 25 to 44; 27.8% were from 45 to 64; and 17.9% were 65 years of age or older.
Chillicothe was the first and third capital of Ohio and is located in southern Ohio along the Scioto River.
The town's name comes from the Shawnee Chala·ka·tha, named after one of the five major divisions of the Shawnee people, as it was the chief settlement of that tribal division.
It was after the American Revolution that most European settlement came to this area.The population density was 2,283.7 people per square mile (882.1/km²).There were 10,303 housing units at an average density of 1,079.5 per square mile (417.0/km²).They created a vibrant community and aided runaway slaves coming north.
As tensions increased prior to the breakout of the American Civil War, the free black community at Chillicothe maintained stations and aid to support refugees on the Underground Railroad.
The racial makeup of the city was 89.21% White, 7.51% African American, 0.34% Native American, 0.56% Asian, 0.04% Pacific Islander, 0.35% from other races, and 2.00% from two or more races.